Procaine Hydrochloride was first synthesized in 1905 by a German chemist Albert Einhorn. He was looking for a compound that would act as an anesthetic, would be non-toxic, free of side effects, and would not be addictive. Dr. Einhorn was looking for a compound that could replace cocaine as an anesthetic. Cocaine was being used at the time as an anesthetic. However, because cocaine was toxic, addictive, and destructive to the central nervous system, its use was being outlawed. Dr. Einhorn was able to produce a compound that demonstrated the properties he was looking for. This new compound he named procaine. “Pro” means, in place of, and “caine” comes from the word cocaine. Because of the similarity of the names and because they are both anesthetics, there is much confusion as to the nature of procaine. Procaine when injected into the muscles acts as an anesthetic but when taken orally in a complexed form procaine acts as a vitamin. Procaine HCl solutions, used as anesthetics, are tradenamed Novocaine.

Chemically procaine is the PABA ester of the amino alcohol DEAE. PABA (p-amino-benzoic acid), is a “B” vitamin. DEAE, (n,n diethylaminoethanol) is a biologically active precursor of the “B” vitamin choline. (Fig. 1) Procaine is usually used in the form of the hydrochloride salt (procaine HCl) because it is highly water soluble. Procaine hydrochloride, when taken orally, enters the body by being mainly absorbed through the villi in the small intestine. Experiments show that the bulk of the procaine HCl enters the bloodstream molecularly intact. In the blood stream procaine HCl is rapidly hydrolyzed by the enzyme pseudo-cholinesterase into PABA and DEAE the two components of the procaine molecule. These metabolites are removed by the liver, chemically changed, and excreted in the urine.

In the late 1940’s Dr. Ana Aslan a Romanian cardiologist found that adding a small amount of benzoic acid to the procaine solution stabilized some of the procaine enough to protect it from the blood enzymes. This protected procaine which Dr. Aslan named Gerovital H3 or GH3 was found to be very helpful in supplying PABA and DEAE to damaged and\or diseased cells. Ana Aslan named the procaine vitamin H-3. GH3 is listed under H-3 in the Merck index.

Procaine HCl when combined with biologically active acids(1) such as folic acid, biotin,ascorbic acid, pantothenic acid, citric acid and many other acids such as amino acids etc., acts as a vitamin or food supplement. The vitamin acids and other biologically active acids when complexed with the procaine HCl molecule protect the procaine from the enzymes in the blood allowing the procaine to enter the cells. These vitamin complexes help the cells assimilate and utilize nutrients more efficiently. These complexed procaine compounds were named by Dr. Robert B Koch.

Procaine HCl (procaine hydrochloride) is the active ingredient in Gerovital H3 (GH3) and in the iGH3, iGH7, iGH7 Plus, iGH8, and iGH9. Procaine HCl is broken down rapidly by enzymes in the blood stream into PABA and DEAE. The PABA and DEAE are rapidly conjugated and removed from the blood and excreted from the body. Because of this procaine HCl and its breakdown products (metabolites) are unable to get into the cells in any great quantity to produce benefits. Procaine HCl will produce some benefits by itself, but they are very limited.

However when procaine HCl is complexed properly (Koch process)(1) the procaine HCl is protected from the action of the enzymes in the blood and tissues this protection gives the procaine enough time to be transfered into the cells of the body where it helps the cells rebuild, repair, and detoxify. This action of the procaine HCl complex is responsible for the remarkable improvements in health that result from the use of iGH3, iGH7, iGH7 Plus, iGH8, and iGH9.

Many companies claim to make GH3. Based on my testing the only GH3 procaine HCl based products that contain the active GH3 factor or properly complexed procaine HCl are Ana Aslan’s injectable GH3 and the iGH3, iGH7, iGH7 Plus, iGH8, and iGH9 produced by Dr. Robert B. Koch. Some companies are totally fraudulent in their claims quoting Ana Aslans case studies and my case studies and research to validate their products which contain no procaine HCl or its complexes. Their products contain PABA and DMAE which they claim produce procaine in the body. This is false because procaine contains no DMAE (dimethylaminoethanol). In fact the DMAE when it enters the cells of the body is broken down and is oxidized producing by products (metabolites) that are damaging and toxic to the cells ( i.e formaldehyde and methyl alcohol). Whereas the DEAE (diethylaminoethanol) from the procaine HCl breaks down in the cells and is oxidized producing acetyl groups that are very valuable for producing acetylcholine and other materials necessary for cellular health.

Other companies produce GH3 and similar products that contain procaine HCl and the other ingredients necessary to make GH3 and list them on their labels but they do not have a valid product. They mix the dry ingredients together and tablet them or put them in capsules without first forming the procaine complexes. I like to use the example of making the candy called fudge. Fudge contains sugar, cocoa, condensed milk, butter and a pinch of salt. If you mix all of these together you have the correct formula but you only have a gritty cocoa in canned milk with a chunk of butter far from being Fudge. However if you cook the ingredients to the soft ball stage and then allow it to cool , then beat it properly to the right crystalline structure you end up with a delicious delight called fudge.

Procaine Based Nutriments (PBNs) as I prefer to call the procaine HCl complexes or GH3 factor must be formed or the product won’t be very effective in helping cells heal and overcome their problems. Effective GH3 products in tablets or capsules containing PBNs will show on their labels not only the correct ingredients but they will also show the patent numbers(1) of the Koch process for forming the complexes of procaine.

Related Procaine HCL supplement products: iGH3, iGH7, iGH7 Plus, iGH8, and iGH9